C1.1 Enzymes and metabolism
Enzymes are globular protein catalysts whose active site lowers activation energy via induced-fit binding. Rate is governed by temperature, pH and substrate concentration (collision theory + denaturation). HL: intracellular vs extracellular reactions, cyclic vs linear pathways, and the four inhibition types (competitive · non-competitive · feedback · mechanism-based) with statins, isoleucine and penicillin as named examples.
Enzyme structure and induced-fit specificitySign up
Active site + induced fit · Molecular motion + immobilised enzymes
Factors affecting enzyme activitySign up
Temperature, pH, [S] + collision theory · Activation energy + denaturation
Anabolic vs catabolic pathways (AHL)HLSign up
Pathways — location + topology (HL) · Four inhibition types (HL)